Pyripyropene A是一种可口服的高效、选择性甾醇O-酰基转移酶2抑制剂，体内研究证实，该化合物能够有效减轻高胆固醇血症并抑制动脉粥样硬化的发展。
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-25~-15℃避光保存，有效期3年。
[1] Hayashi A, Arai M, Fujita M, Kobayashi M. Pyripyropenes, fungal sesquiterpenes conjugated with alpha-pyrone and pyridine moieties, exhibits anti-angiogenic activity against human umbilical vein endothelial cells. Biol Pharm Bull. 2009 Jul;32(7):1261-5. doi: 10.1248/bpb.32.1261. PMID: 19571395.[2]Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia. Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. doi: 10.1161/ATVBAHA.111.223552. Epub 2011 Mar 10. PMID: 21393580.
