Proadifen hydrochloride是一种非竞争性细胞色素P450抑制剂，可降低大鼠单胺氧化酶A活性并逆转丙咪嗪与地昔帕明的抗抑郁样行为；该化合物还能抑制肝微粒体对N,N-二甲基色胺的代谢(阻断N-去甲基化及吖啶酮形成)，并增强脂多糖诱导的大鼠发热反应与前列腺素E2水平升高，适用于代谢性疾病、卵巢癌、炎症及多巴胺神经元相关疾病的研究。
| 英文别名 (English Synonym) | Proadifen hydrochloride |
| 中文名称 (Chinese Name) | 盐酸普罗地芬；普罗地芬盐酸盐 |
| 靶点 (Target) | P450 |
| 通路 (Pathway) | Protease/Metabolic Enzyme |
| CAS号 (CAS NO.) | 62-68-0 |
| 分子式 (Formula) | C23H31NO2·HCl |
| 分子量 (Molecular Weight) | 390.0 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Eckernäs E, Macan-Schönleben A, Andresen-Bergström M, Birgersson S, Hoffmann KJ, Ashton M. N, N-dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation. Xenobiotica. 2023 Dec;53(8-9):515-522. doi: 10.1080/00498254.2023.2278488. Epub 2023 Nov 26. PMID: 37916667.
[2] Wieslaw Kozak, Kimberly P Mayfield, Anna Kozak, Matthew J Kluger,Proadifen (SKF-525A), an inhibitor of cytochrome P-450, augments LPS-induced fever and exacerbates prostaglandin-E2 levels in the rat,Journal of Thermal Biology,Volume 25, Issues 1–2,2000,Pages 45-50,ISSN 0306-4565,https://doi.org/10.1016/S0306-4565(99)00067-4.
