Isotretinoin是一种口服有效的维生素A衍生物，临床用于重度痤疮的治疗研究，并表现出抗肿瘤活性。
| 英文别名 (English Synonym) | Isotretinoin |
| 中文名称 (Chinese Name) | 异维A酸 |
| 靶点 (Target) | Dopamine β-hydroxylase |
| 通路 (Pathway) | Protease/Metabolic Enzyme |
| CAS号 (CAS NO.) | 4759-48-2 |
| 分子式 (Formula) | C20H28O2 |
| 分子量 (Molecular Weight) | 300.44 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ramírez-Flores PN, Barraza-Reyna PJ, Aguirre-Vázquez A, Camacho-Moll ME, Guerrero-Beltrán CE, Resendez-Pérez D, González-Villasana V, Garza-González JN, Silva-Ramírez B, Castorena-Torres F, Bermúdez de León M. Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells. Molecules. 2021 Sep 22;26(19):5742. doi: 10.3390/molecules26195742. PMID: 34641286; PMCID: PMC8510077.
[2] Dahl AR, Grossi IM, Houchens DP, Scovell LJ, Placke ME, Imondi AR, Stoner GD, De Luca LM, Wang D, Mulshine JL. Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study. Clin Cancer Res. 2000 Aug;6(8):3015-24. PMID: 10955779.
