Gabexate mesylate (FOY)是一种竞争性、非抗原性的合成胰蛋白酶样丝氨酸蛋白酶抑制剂。它能有效抑制凝血酶、尿激酶、纤溶酶及Xa因子等多种蛋白酶,并与人和牛类胰蛋白酶结合。该药物通过抑制凝血酶发挥抗凝作用,并通过阻断NF-κB通路、促炎细胞因子及一氧化氮产生抗炎效果,临床用于治疗胰腺炎和弥散性血管内凝血。
|
英文别名 (English Synonym) |
Gabexate mesylate |
|
中文名称 (Chinese Name) |
甲磺酸加贝酯 |
|
靶点 (Target) |
Serine Protease |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
56974-61-9 |
|
分子式 (Formula) |
C16H23N3O4·CH4O3S |
|
分子量 (Molecular Weight) |
417.48 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ozeki T, Natori T. The specific inhibition of HepG2 cells proliferation by apoptosis induced by gabexate mesilate. Int J Clin Exp Pathol. 2010 Aug 15,3(7):710-7. PMID: 20830242, PMCID: PMC2933391.[2]Oh SH, Lee HY, Ki YJ, Kim SH, Lim KJ, Jung KT. Gabexate mesilate ameliorates the neuropathic pain in a rat model by inhibition of proinflammatory cytokines and nitric oxide pathway via suppression of nuclear factor-κB. Korean J Pain. 2020 Jan 1,33(1):30-39. doi: 10.3344/kjp.2020.33.1.30. PMID: 31888315, PMCID: PMC6944363.
