Quinacrine dihydrochloride是一种口服有效的抗疟剂,其在体内外均被鉴定具有抗肿瘤活性,该作用源于其对 NF-κB 的抑制及对 p53 的激活所介导的细胞凋亡。
|
英文别名 (English Synonym) |
Quinacrine 2HCl |
|
中文名称 (Chinese Name) |
阿的平 |
|
靶点 (Target) |
Phospholipase |
|
通路 (Pathway) |
Protease/Metabolic Enzyme |
|
CAS号 (CAS NO.) |
69-05-6 |
|
分子式 (Formula) |
C23H30ClN3O·2HCl |
|
分子量 (Molecular Weight) |
472.88 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Wu X, Wang Y, Wang H, Wang Q, Wang L, Miao J, Cui F, Wang J. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb,73(1-2):52-64. doi: 10.1016/j.curtheres.2012.02.003. PMID: 24653512, PMCID: PMC3954015.[2]Eriksson A, Chantzi E, Fryknäs M, Gullbo J, Nygren P, Gustafsson M, Höglund M, Larsson R. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec,63:41-46. doi: 10.1016/j.leukres.2017.10.012. Epub 2017 Oct 28. PMID: 29100024.
