Maraviroc是一种选择性CCR5拮抗剂,具有抗HIV活性。
|
英文别名 (English Synonym) |
Maraviroc |
|
中文名称 (Chinese Name) |
马拉维若 |
|
靶点 (Target) |
HIV |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
376348-65-1 |
|
分子式 (Formula) |
C29H41F2N5O |
|
分子量 (Molecular Weight) |
513.67 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Dorr P, Westby M, Dobbs S, Griffin P, Irvine B, Macartney M, Mori J, Rickett G, Smith-Burchnell C, Napier C, Webster R, Armour D, Price D, Stammen B, Wood A, Perros M. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005 Nov,49(11):4721-32. doi: 10.1128/AAC.49.11.4721-4732.2005. PMID: 16251317, PMCID: PMC1280117.
