Xylometazoline hydrochloride是一种 α-肾上腺素能受体激动剂（Ki=0.05-1.7 μM）,通过收缩鼻腔血管、增加鼻腔气流,用于鼻塞与流鼻涕的研究。
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英文别名 (English Synonym) |
Xylometazoline HCl |
|
中文名称 (Chinese Name) |
盐酸赛洛唑啉 |
|
靶点 (Target) |
Adrenergic Receptor |
|
通路 (Pathway) |
GPCR/G protein |
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CAS号 (CAS NO.) |
1218-35-5 |
|
分子式 (Formula) |
C16H24N2·HCl |
|
分子量 (Molecular Weight) |
280.84 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Haenisch B, Walstab J, Herberhold S, Bootz F, Tschaikin M, Ramseger R, Bönisch H. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec,24(6):729-39. doi: 10.1111/j.1472-8206.2009.00805.x. PMID: 20030735.[2]Kar M, Ince I, Yildirim C, Burukoğlu Dönmez D, Karasulu Y, Cingi C. Development of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment. Eur Rev Med Pharmacol Sci. 2022 Dec,26(2 Suppl):65-71. doi: 10.26355/eurrev_202212_30486. PMID: 36524913.
