Clodronic acid disodium salt (Clodronate)是第一代口服活性的双磷酸盐,通过抑制破骨细胞骨吸收,用于治疗高骨转换状态、Paget's病及溶骨性骨转移。
|
英文别名 (English Synonym) |
Clodronic acid disodium salt |
|
中文名称 (Chinese Name) |
氯屈膦酸二钠 |
|
靶点 (Target) |
Others |
|
通路 (Pathway) |
Others |
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CAS号 (CAS NO.) |
22560-50-5 |
|
分子式 (Formula) |
CH2Cl2Na2O6P2 |
|
分子量 (Molecular Weight) |
288.86 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Tanakol R, Yarman S, Bayraktaroglu T, Boztepe H, Alagöl F. Clodronic acid in the treatment of postmenopausal osteoporosis. Clin Drug Investig. 2007,27(6):419-33. doi: 10.2165/00044011-200727060-00005. PMID: 17506592.[2]Itoh F, Aoyagi S, Kusama H, Kojima M, Kogo H. Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis. Inflammation. 2004 Feb,28(1):15-21. doi: 10.1023/b:ifla.0000014707.49803.b6. PMID: 15072226.
