Erdafitinib (JNJ-42756493)是一种有效的口服FGFR家族抑制剂。
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英文别名 (English Synonym) |
Erdafitinib |
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中文名称 (Chinese Name) |
厄达替尼 |
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靶点 (Target) |
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通路 (Pathway) |
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CAS号 (CAS NO.) |
1346242-81-6 |
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分子式 (Formula) |
C25H30N6O2 |
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分子量 (Molecular Weight) |
446.54 |
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纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Perera TPS, Jovcheva E, Mevellec L, Vialard J, De Lange D, Verhulst T, Paulussen C, Van De Ven K, King P, Freyne E, Rees DC, Squires M, Saxty G, Page M, Murray CW, Gilissen R, Ward G, Thompson NT, Newell DR, Cheng N, Xie L, Yang J, Platero SJ, Karkera JD, Moy C, Angibaud P, Laquerre S, Lorenzi MV. Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor. Mol Cancer Ther. 2017 Jun,16(6):1010-1020. doi: 10.1158/1535-7163.MCT-16-0589. Epub 2017 Mar 24. PMID: 28341788.
