Albendazole (SKF-62979)是一种口服有效的广谱抗寄生虫剂,具有高效低毒的特点,可用于人类和动物的胃肠道寄生虫研究。在抗癌方面,它能诱导癌细胞凋亡与自噬,抑制细胞增殖与周期进程,其作用机制与抑制微管蛋白聚合、HIF-1α/VEGF表达、糖酵解过程及抗氧化活性相关。
|
英文别名 (English Synonym) |
Albendazole |
|
中文名称 (Chinese Name) |
阿苯达唑 |
|
靶点 (Target) |
Antibiotic |
|
通路 (Pathway) |
Microbiology/Virology |
|
CAS号 (CAS NO.) |
54965-21-8 |
|
分子式 (Formula) |
C12H15N3O2S |
|
分子量 (Molecular Weight) |
265.33 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Jung YY, Baek SH, Ha IJ, Ahn KS. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells. Biochimie. 2022 Jul,198:155-166. doi: 10.1016/j.biochi.2022.04.014. Epub 2022 Apr 30. PMID: 35504402.[2]Vural G, Yardimci M, Kocak M, Yasar TÖ, Kurt A, Harem IS, Carradori S, Sciamanna I, Siles-Lucas M, Fabiani M, Hemphill A, Lundström-Stadelmann B, Cirilli R, Casulli A. Efficacy of novel albendazole salt formulations against secondary cystic echinococcosis in experimentally infected mice. Parasitology. 2020 Nov,147(13):1425-1432. doi: 10.1017/S0031182020001225. Epub 2020 Jul 30. PMID: 32729453, PMCID: PMC10317756.
