Efavirenz是一种合成非核苷类逆转录酶抑制剂,可有效抑制野生型HIV-1逆转录酶及病毒复制,具有强效抗病毒活性。
| 英文别名 (English Synonym) | Efavirenz |
| 中文名称 (Chinese Name) | 依法韦仑 |
| 靶点 (Target) | HIV |
| 通路 (Pathway) | Microbiology/Virology |
| CAS号 (CAS NO.) | 154598-52-4 |
| 分子式 (Formula) | C14H9ClF3NO2 |
| 分子量 (Molecular Weight) | 315.68 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存,有效期3年
[1] Young SD, Britcher SF, Tran LO, Payne LS, Lumma WC, Lyle TA, Huff JR, Anderson PS, Olsen DB, Carroll SS, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. doi: 10.1128/AAC.39.12.2602. PMID: 8592986; PMCID: PMC162996.[2]Held DM, Kissel JD, Saran D, Michalowski D, Burke DH. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22. doi: 10.1074/jbc.M604460200. Epub 2006 Jun 23. PMID: 16798747.[3]Grobler JA, Dornadula G, Rice MR, Simcoe AL, Hazuda DJ, Miller MD. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282(11):8005-10. doi: 10.1074/jbc.M608274200. Epub 2006 Dec 15. PMID: 17172472.





