Dioscin是一种天然甾体皂苷，对多种癌细胞具有显著抗癌活性。该化合物通过诱导ROS介导的DNA损伤、激活线粒体通路及促凋亡机制，在HeLa和SiHa细胞中引发DNA损伤与细胞凋亡。
| 英文别名 (English Synonym) | Dioscin |
| 中文名称 (Chinese Name) | 薯蓣皂甙 |
| 靶点 (Target) | Others |
| 通路 (Pathway) | Natural Products |
| CAS号 (CAS NO.) | 19057-60-4 |
| 分子式 (Formula) | C45H72O16 |
| 分子量 (Molecular Weight) | 869.05 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016 Jun 4;21(6):730. doi: 10.3390/molecules21060730. Erratum in: Molecules. 2020 Jan 06;25(1):E232. doi: 10.3390/molecules25010232. PMID: 27271587; PMCID: PMC6273920.
[2] Xu T, Zhang S, Zheng L, Yin L, Xu L, Peng J. A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats. Food Chem Toxicol. 2012 May;50(5):1279-87. doi: 10.1016/j.fct.2012.02.027. Epub 2012 Feb 22. Erratum in: Food Chem Toxicol. 2019 Oct;132:110697. doi: 10.1016/j.fct.2019.110697. PMID: 22386816.
