Chlorotrianisene是一种口服活性、长效的非甾体雌激素,具有抗雌激素活性,并能通过有效抑制COX-1来抑制全血血小板聚集。
|
英文别名 (English Synonym) |
Chlorotrianisene |
|
中文名称 (Chinese Name) |
氯丁烯二烯 |
|
靶点 (Target) |
Estrogen/progestogen Receptor |
|
通路 (Pathway) |
Endocrinology and Hormones |
|
CAS号 (CAS NO.) |
569-57-3 |
|
分子式 (Formula) |
C23H21ClO3 |
|
分子量 (Molecular Weight) |
380.86 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Ruenitz PC, Moore SA, Kraft KS, Bourne CS. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec,63(4-6):203-9. doi: 10.1016/s0960-0760(97)00118-0. PMID: 9459186.[2]Kupfer D, Bulger WH. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12,261(1):59-62. doi: 10.1016/0014-5793(90)80636-w. PMID: 2307235.
