Nicaraven是一种化学合成的羟基自由基清除剂，具有抗血管痉挛及神经保护作用。
| 英文别名 (English Synonym) | Nicaraven |
| 中文名称 (Chinese Name) | 烟拉文 |
| 靶点 (Target) | Others |
| 通路 (Pathway) | Others |
| CAS号 (CAS NO.) | 79455-30-4 |
| 分子式 (Formula) | C15H16N4O2 |
| 分子量 (Molecular Weight) | 284.31 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Komiya T, Higurashi K, Iizuka K, Mizuno Y. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. doi: 10.1097/00002826-199901000-00003. PMID: 10047928.[2]Yokota R, Fukai M, Shimamura T, Suzuki T, Watanabe Y, Nagashima K, Kishida A, Furukawa H, Hayashi T, Todo S. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. doi: 10.1067/msy.2000.105864. PMID: 10840362.[3]Ali H, Galal O, Urata Y, Goto S, Guo CY, Luo L, Abdelrahim E, Ono Y, Mostafa E, Li TS. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. Biochem Biophys Res Commun. 2014 Sep 26;452(3):548-53. doi: 10.1016/j.bbrc.2014.08.112. Epub 2014 Aug 28. PMID: 25173934.[4]Kawakatsu M, Urata Y, Imai R, Goto S, Ono Y, Nishida N, Li TS. Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. doi: 10.1371/journal.pone.0060023. Epub 2013 Mar 29. PMID: 23555869; PMCID: PMC3612087.
