Ethosuximide是一种琥珀酰亚胺类抗癫痫药物，通过阻断低电压激活的T型钙通道发挥作用，主要用于失神性发作的治疗，并在多种神经退行性疾病模型中表现出表型改善作用。
| 英文别名 (English Synonym) | Ethosuximide |
| 中文名称 (Chinese Name) | 乙琥胺 |
| 靶点 (Target) | Calcium Channel |
| 通路 (Pathway) | Membrane Transporter/Ion Channel |
| CAS号 (CAS NO.) | 77-67-8 |
| 分子式 (Formula) | C7H11NO2 |
| 分子量 (Molecular Weight) | 141.17 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Chen X, McCue HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51. doi: 10.1186/s13024-015-0046-3. Erratum in: Mol Neurodegener. 2015 Oct 23;10:54. doi: 10.1186/s13024-015-0051-6. PMID: 26419537; PMCID: PMC4587861.[2]Sondossi K, Majdzadeh M, Ghaeli P, Ghahremani MH, Shafaroodi H, Paknejad B, Ostad SN. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28(5):512-8. doi: 10.1111/fcp.12061. Epub 2014 Jan 21. PMID: 24354536.
