Amodiaquine dihydrochloride为4-氨基喹啉类抗疟剂，口服有效，兼具抗炎活性：作为组胺N-甲基转移酶抑制剂，同时可特异性结合Nurr1配体结合域发挥激动作用。
| 英文别名 (English Synonym) | Amodiaquine dihydrochloride |
| 中文名称 (Chinese Name) | 阿莫地喹二盐酸盐 |
| 靶点 (Target) | HnMT |
| 通路 (Pathway) | Immunology/Inflammation |
| CAS号 (CAS NO.) | 69-44-3 |
| 分子式 (Formula) | C20H24Cl3N3O |
| 分子量 (Molecular Weight) | 428.78 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, Nguyen QT, Sohn M, Kim WG, Han M, Jeong I, Kim KS, Lee EH, Tu Y, Naffin-Olivos JL, Park CH, Ringe D, Yoon HS, Petsko GA, Kim KS. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61. doi: 10.1073/pnas.1509742112. Epub 2015 Jun 29. PMID: 26124091; PMCID: PMC4507186.
[2] Kinoshita K, Matsumoto K, Kurauchi Y, Hisatsune A, Seki T, Katsuki H. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54. doi: 10.1016/j.jneuroim.2019.02.010. Epub 2019 Feb 22. PMID: 30825859.
