Reserpine是一种囊泡单胺转运蛋白2抑制剂，作为吲哚类生物碱，具有抗精神病与降压作用，亦用于构建胃肠溃疡动物模型。
| 英文别名 (English Synonym) | Reserpine |
| 中文名称 (Chinese Name) | 利血平 |
| 靶点 (Target) | Others |
| 通路 (Pathway) | Natural Products |
| CAS号 (CAS NO.) | 50-55-5 |
| 分子式 (Formula) | C33H40N2O9 |
| 分子量 (Molecular Weight) | 608.27 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Antkiewicz-Michaluk L, Wąsik A, Możdżeń E, Romańska I, Michaluk J. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54. doi: 10.1016/j.pnpbp.2014.10.009. Epub 2014 Nov 8. PMID: 25445479.[2]Hong B, Su Z, Zhang C, Yang Y, Guo Y, Li W, Kong AN. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18(3):659-69. doi: 10.1208/s12248-016-9901-6. Epub 2016 Mar 17. PMID: 26988984; PMCID: PMC5256618.[3]El-Marasy SA, El Awdan SA, Hassan A, Ahmed-Farid OA, Ogaly HA. Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. Chem Biol Interact. 2021 Jan 25;334:109329. doi: 10.1016/j.cbi.2020.109329. Epub 2020 Dec 3. PMID: 33279466.[4]Sreemantula S, Boini KM, Nammi S. Reserpine methonitrate, a novel quaternary analogue of reserpine augments urinary excretion of VMA and 5-HIAA without affecting HVA in rats. BMC Pharmacol. 2004 Nov 16;4:30. doi: 10.1186/1471-2210-4-30. PMID: 15546495; PMCID: PMC535563.
