Isavuconazole是一种广谱三唑类抗真菌前药，通过抑制细胞色素P450依赖的14α-羊毛甾醇去甲基化酶，阻断麦角固醇合成，破坏真菌细胞膜完整性。该化合物对酵母、霉菌及双相真菌均具活性，且对CYP3A4酶有中度抑制作用。
| 英文别名 (English Synonym) | Isavuconazole |
| 中文名称 (Chinese Name) | 艾沙康唑 |
| 靶点 (Target) | Antifungal |
| 通路 (Pathway) | Microbiology/Virology |
| CAS号 (CAS NO.) | 241479-67-4 |
| 分子式 (Formula) | C22H17F2N5OS |
| 分子量 (Molecular Weight) | 437.47 |
| 纯度 (Purity) | ≥98% |
| 溶解性 (Solubility) | 溶于DMSO |
-25~-15℃保存，有效期3年
[1] Steinmann J, Dittmer S, Houbraken J, Buer J, Rath PM. In Vitro Activity of Isavuconazole against Rasamsonia Species. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6890-6891. doi: 10.1128/AAC.00742-16. PMID: 27527087; PMCID: PMC5075100.[2]Donnelley MA, Zhu ES, Thompson GR 3rd. Isavuconazole in the treatment of invasive aspergillosis and mucormycosis infections. Infect Drug Resist. 2016 Jun 2;9:79-86. doi: 10.2147/IDR.S81416. PMID: 27330318; PMCID: PMC4898026.[3]Box H, Livermore J, Johnson A, McEntee L, Felton TW, Whalley S, Goodwin J, Hope WW. Pharmacodynamics of Isavuconazole in a Dynamic In Vitro Model of Invasive Pulmonary Aspergillosis. Antimicrob Agents Chemother. 2015 Oct 26;60(1):278-87. doi: 10.1128/AAC.01364-15. PMID: 26503648; PMCID: PMC4704219.
