Penciclovir（VSA 671）是一种高效选择性抗疱疹病毒化合物，其对HSV-1（HFEM株）和HSV-2（MS株）的半数有效浓度（EC50）分别为0.5 μg/ml和0.8 μg/ml。该药物在显著抑制疱疹病毒复制的同时未表现细胞毒性，并能有效预防疱疹病毒感染所致的小鼠死亡。
|
英文别名 (English Synonym) |
Penciclovir |
|
中文名称 (Chinese Name) |
喷昔洛韦 |
|
靶点 (Target) |
Nucleoside Antimetabolite/Analogue |
|
通路 (Pathway) |
Cell Cycle/DNA Damage |
|
CAS号 (CAS NO.) |
39809-25-1 |
|
分子式 (Formula) |
C10H15N5O3 |
|
分子量 (Molecular Weight) |
253.26 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11. [2] de la Fuente R, Awan AR, Field HJ. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89. doi: 10.1016/0166-3542(92)90007-r. PMID: 1329646.
