柠檬酸是一种广泛用作防腐剂、酸化剂、乳化剂、螯合剂和缓冲剂的食品添加剂。在工业应用之外，研究发现其可在生物体内诱导HaCaT细胞发生凋亡并使细胞周期阻滞于G2/M期和S期，同时可能通过降低抗氧化酶活性导致肝脏氧化损伤。
|
英文别名 (English Synonym) |
Citricacid |
|
中文名称 (Chinese Name) |
柠檬酸 |
|
靶点 (Target) |
Reagents |
|
通路 (Pathway) |
Others |
|
CAS号 (CAS NO.) |
77-92-9 |
|
分子式 (Formula) |
C6H8O7 |
|
分子量 (Molecular Weight) |
192.12 |
|
纯度 (Purity) |
≥98% |
|
溶解性 (Solubility) |
溶于H2O |
-25~-15℃保存，有效期3年
[1] Ying TH, Chen CW, Hsiao YP, Hung SJ, Chung JG, Yang JH. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct;33(10):4411-20. PMID: 24123010.[2]Chen X, Lv Q, Liu Y, Deng W. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. doi: 10.1007/s10616-013-9567-1. Epub 2013 Apr 21. Erratum in: Cytotechnology. 2016 Oct;68(5):2209. doi: 10.1007/s10616-016-9978-x. PMID: 23606053; PMCID: PMC3918259.
