钩果草苷是一种从钩果草中分离得到的口服活性化合物，具有抗炎、抗癌和神经保护等多重药理活性；它通过抑制COX-1/2活性和NO产生发挥抗炎作用，并能抑制HepG2细胞中脂多糖诱导的炎症因子表达，同时还具有对抗β-淀粉样肽诱导的神经退行性变的神经保护活性。
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英文别名 (English Synonym) |
Harpagoside |
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中文名称 (Chinese Name) |
|
|
靶点 (Target) |
GMNN - geminin, DNA replication inhibitor (human) |
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通路 (Pathway) |
Natural Products |
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CAS号 (CAS NO.) |
19210-12-9 |
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分子式 (Formula) |
C24H30O11 |
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分子量 (Molecular Weight) |
494.18 |
|
纯度 (Purity) |
≥98% |
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溶解性 (Solubility) |
溶于DMSO |
-25~-15℃保存，有效期3年
[1] Huang, T. H., Tran, V. H., Duke, R. K., Tan, S., Chrubasik, S., Roufogalis, B. D., & Duke, C. C. (2006). Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation. Journal of Ethnopharmacology, 104(1-2), 149-155. [2]Wang, Z., Huang, Y., Cheng, Y., et al. (2016). Antidepressant-like effects of albiflorin extracted from Radix Paeoniae Alba. Journal of Ethnopharmacology, 179, 9-15.
