RI-1是RAD51选择性抑制剂，IC₅₀为5-30 µM，通过与RAD51蛋白的319位半胱氨酸共价结合，破坏RAD51单体用于寡聚化成DNA细丝的界面，进而抑制RAD51活性，破坏细胞中的同源重组。

参考文献

[1] Budke B, Logan HL, Kalin JH, et al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug;40(15):7347-57. doi: 10.1093/nar/gks353(IF:11.147).

[2] Shi Y, Jin J, Wang X, et al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun;21(6):533-544. doi: 10.1016/j.neo.2019.04.001(IF:3.837).

-25~-15℃保存，有效期3年。