UPF 1069 (UPF1069)是异喹啉酮的衍生物，是PARP抑制剂，作用于PARP1/2的IC₅₀值约为8 µM和0.3 µM。聚ADP核糖聚合酶PARPs在DNA修复和细胞凋亡中发挥作用。

参考文献

[1] Pellicciari R, Camaioni E, Costantino G, et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008 Jun;3(6):914-23. doi: 10.1002/cmdc.200800010(IF:3.016).

[2] Moroni F, Formentini L, Gerace E, et, al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br J Pharmacol. 2009 Jul;157(5):854-62. doi: 10.1111/j.1476-5381.2009.00232.x(IF:6.583).

-25~-15℃保存，有效期3年。