Droxinostat (NS 41080, NS41080)是HDAC抑制剂，作用于HDAC3/6/8的IC₅₀为16.9 μM、2.47 μM和1.46 μM，对其它HDAC成员效果不明显。Droxinostat是死亡受体的敏化剂，能诱导细胞凋亡。

参考文献

[1] Mawji IA, et al. Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. J Natl Cancer Inst. 2007 May 16;99(10):811-22.

[2] Liu J, et al. Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP. Transl Oncol. 2016 Feb;9(1):70-8.

[3] Wood TE et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。