SL-327 (SL327)是MEK1/2抑制剂，IC₅₀为0.18 μM/0.22 μM，U0126的结构同系物，能透过血脑屏障，可通过抑制MAPK/ERK磷酸化阻断大鼠的恐惧调节和学习。

参考文献

[1] Scherle PA, et al. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J Biol Chem. 2000 Nov 24;275(47):37086-92.

[2] Selcher JC, et al. A necessity for MAP kinase activation in mammalian spatial learning. Learn Mem. 1999 Sep-Oct;6(5):478-90.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。