Procaine hydrochloride (Novocaine HCl; Procaine HCl)，又称盐酸普鲁卡因、盐酸普罗卡因、盐酸奴佛卡因、盐酸奴呋卡因或盐酸奴夫卡因，是局部麻醉药，临床上主要用于浸润、脊椎及传导麻醉。盐酸普鲁卡因是一种Na ⁺通道阻滞剂，IC₅₀为60 μM。盐酸普鲁卡因也是DNA脱甲基化剂，结合CpG富集的DNA，使密集的高甲基化CpG序列脱甲基，导致表观遗传学上沉默的基因恢复基因表达。

参考文献

1.Fan, P. and F.F. Weight, Procaine impairs the function of 5-HT3 receptor-ion channel complex in rat sensory ganglion neurons. Neuropharmacology. 1994 Dec;33(12):1573-9.

2.Villar-Garea, A., et al., Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. Cancer Res. 2003 Aug 15;63(16):4984-9.

3.Adamec, R.E. and C. Stark-Adamec, The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):345-64.

4.Adamec RE, et al. The effects of procaine HCl on population cellular and evoked response activity within the limbic system of the cat. Evidence for differential excitatory action of procaine in a variety of limbic circuits. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):345-64.

5.Racine R, et al. Effects of procaine hydrochloride, diazepam, and diphenylhydantoin on seizure development in cortical and subcortical structures in rats. Electroencephalogr Clin Neurophysiol. 1975 Apr;38(4):355-65.

冰袋运输。粉末直接保存于-20℃，有效期3年。建议分装后-20℃干燥保存，避免反复冻融。