N-Desmethyltamoxifen是Tamoxifen在三苯氧胺的主要代谢产物，属于PKC抑制剂（蛋白激酶C抑制剂），可以显著抑制胶质瘤细胞系（T98G、U8、U138、U37、ALW、AUK、CAS细胞）增殖，抑制人乳腺癌细胞生长，具有抗肿瘤活性。

参考文献

[1]. Vertosick FT Jr, et al. A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro. J Neurooncol. 1994;19(2):97-103.

[2]. Morad SA, et al. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics. Biochim Biophys Acta. 2015 Jul;1851(7):919-28.

[3]. Reddel RR,et al. N-desmethyltamoxifen inhibits growth of MCF 7 human mammary carcinoma cells in vitro. Eur J Cancer Clin Oncol. 1983 Aug;19(8):1179-81.

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