Reversine，又称逆转素，是一种强效A3 adenosine receptor拮抗剂，K_i为0.66 μM，能促进定型细胞去分化为多能祖细胞型细胞；也是一种Aurora kinase抑制剂，具有抗肿瘤活性，Aurora激酶是丝氨酸/苏氨酸激酶，在有丝分裂调控中起关键作用，在人类肿瘤中经常过表达。Reversine作用于Aurora A/B/C kinase，IC₅₀分别为400 nM/500 nM/400 nM。

参考文献

1.D'Alise AM, et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol Cancer Ther. 2008 May;7(5):1140-9.

2.Chen S, et al. Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc. 2004 Jan 21;126(2):410-1.

3.Qin HX, et al. Synergistic antitumor activity of reversine combined with aspirin in cervical carcinoma in vitro and in vivo. Cytotechnology. 2013 Aug;65(4):643-53.

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