This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants.

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Western blotting analysis using SUMO specific peptidase 1 antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with SUMO specific peptidase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

Western blotting analysis using SUMO specific peptidase 1 antibody . SUMO specific peptidase 1 expression in wild-type (WT) and SUMO specific peptidase 1 (SENP1) knockdown (KD) HSHC cells with 20 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with SUMO specific peptidase 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

Flow cytometric analysis of SUMO specific peptidase 1 expression in HepG2 cells using SUMO specific peptidase 1 antibody . Green, isotype control; red, SUMO specific peptidase 1.

Immunocytochemical staining of HepG2 cells with SUMO specific peptidase 1 antibody . Nuclei were stained blue with DAPI; SUMO specific peptidase 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.

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