This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion.

推荐稀释比 WB: 1/1000-1/5000; FC: 1/200-1/2000; ICC/IF: 1/100-1/1000

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Flow cytometric analysis of Cytoplasmic FMR1 interacting protein 1 expression in HepG2 cells using Cytoplasmic FMR1 interacting protein 1 antibody . Green, isotype control; red, Cytoplasmic FMR1 interacting protein 1.

Immunocytochemical staining of HepG2 cells with Cytoplasmic FMR1 interacting protein 1 antibody . Nuclei were stained blue with DAPI; Cytoplasmic FMR1 interacting protein 1 was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar, 20 μm.

Western blotting analysis using Cytoplasmic FMR1 interacting protein 1 antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with Cytoplasmic FMR1 interacting protein 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

Western blotting analysis using Cytoplasmic FMR1 interacting protein 1 antibody . Cytoplasmic FMR1 interacting protein 1 expression in wild type (WT) and cytoplasmic FMR1 interacting protein 1 shRNA knockdown (KD) Hela cells with 30 μg of total cell lysates. β-Tubulin serves as a loading control. The blot was incubated with Cytoplasmic FMR1 interacting protein 1 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

Immunocytochemical staining of Hela cells using Cytoplasmic FMR1 interacting protein 1 antibody , Top panel: wild-type (WT); Bottom panal: Cytoplasmic FMR1 interacting protein 1 shRNA knockdown (KD). Nuclei were stained blue with DAPI; Cytoplasmic FMR1 interacting protein 1 was stained magenta with Alexa Fluor® 647. Scale bar, 20 μm.

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