This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

推荐稀释比 WB: 1/1000-1/5000; FC: 1/200-1/2000

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Flow cytometric analysis of Phospho-IGF1 Receptor (Tyr1166) expression in HAP-1 cells using Phospho-IGF1 Receptor (Tyr1166) antibody . Green, isotype control; red, Phospho-IGF1 Receptor (Tyr1166).

Western blotting analysis using phospho-IGF1 Receptor (Tyr1166) antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with phospho-IGF1 Receptor (Tyr1166) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

Western blotting analysis using phospho-IGF1 Receptor (Tyr1166) antibody . phospho-IGF1 Receptor (Tyr1166) expression in wild-type (WT) and IGF1R knockout (KO) HT-1080 cells with 30 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with phospho-IGF1 Receptor (Tyr1166) antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

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