The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

推荐稀释比 WB: 1/500-1/2500; FC: 1/1/100-1000

本产品仅用作科学研究！

Flow cytometric analysis of Calcium modulating ligand expression in HeLa cells using Calcium modulating ligand antibody . Green, isotype control; red, Calcium modulating ligand.

Western blotting analysis using calcium modulating ligand antibody . Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with calcium modulating ligand antibody and HRP-conjugated goat anti-mouse secondary antibody respectively. Image was developed using FeQ™ ECL Substrate Kit .

Western blotting analysis using calcium modulating ligand antibody . Calcium modulating ligand expression in wild type (WT) and calcium modulating ligand (CAMLG) shRNA knockdown (KD) HeLa cells with 20 μg of total cell lysates. Hsp90 α serves as a loading control. The blot was incubated with calcium modulating ligand antibody and HRP-conjugated goat anti-mouse secondary antibody respectively. Image was developed using NaQ™ ECL Substrate Kit .

Store at -20℃ for one year.