CLZ-8是一种口服有效的Mcl-1-PUMA相互作用抑制剂，它通过同时抑制Mcl-1介导的抗凋亡活性和下调PUMA依赖的促凋亡信号，从而调控细胞凋亡进程。

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-25~-15℃避光保存，有效期3年。

[1] Liu J, Tian Z, Zhou N, Liu X, Liao C, Lei B, Li J, Zhang S, Chen H. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242. doi: 10.18632/oncotarget.17294. PMID: 28903337; PMCID: PMC5589576.

[2] Feng T, et al. CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo. Environ Toxicol Pharmacol. 2018 Jul;61:44-51