Palosuran hydrochloride(ACT-058362 hydrochloride)是一种口服有效的选择性尿紧张素II受体（UT）拮抗剂，其对表达人重组UT受体的CHO细胞膜具有高抑制活性，并在糖尿病大鼠模型中表现出改善胰腺和肾脏功能的治疗潜力。

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2~8℃避光保存，有效期3年。

[1] Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding SS, Fischli W, Hess P, Mathys B, Morrison K, Müller C, Müller C, Nayler O, Qiu C, Rey M, Scherz MW, Velker J, Weller T, Xi JF, Ziltener P. Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System. J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. doi: 10.1124/jpet.104.068320. Epub 2004 May 14. PMID: 15146030.