P110 heptapeptide具有抗炎、免疫调节、线粒体保护及神经保护活性。作为一种Drp1-Fis1相互作用抑制剂,它能特异性减轻多种疾病模型的病理表现而不干扰Drp1生理功能,故可用于神经系统及炎症性疾病研究。
[1] Rios L, Pokhrel S, Li SJ, Heo G, Haileselassie B, Mochly-Rosen D. Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356. doi: 10.1038/s41467-023-40043-0. PMID: 37468472; PMCID: PMC10356917.[2]Mukherjee R, Tompkins CA, Ostberg NP, Joshi AU, Massis LM, Vijayan V, Gera K, Monack D, Cornell TT, Hall MW, Mochly-Rosen D, Haileselassie B. Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. Crit Care Med. 2022 Jun 1;50(6):e504-e515. doi: 10.1097/CCM.0000000000005437. Epub 2022 Jan 24. PMID: 35067534; PMCID: PMC9133053.





