Cercosporamide是一种高效的ATP竞争性PKC激酶抑制剂。此外，它也是一种独特的Mnk激酶抑制剂。
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-25~-15℃避光保存，有效期3年。
[1] Sussman A, Huss K, Chio LC, Heidler S, Shaw M, Ma D, Zhu G, Campbell RM, Park TS, Kulanthaivel P, Scott JE, Carpenter JW, Strege MA, Belvo MD, Swartling JR, Fischl A, Yeh WK, Shih C, Ye XS. Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Eukaryot Cell. 2004 Aug;3(4):932-43. doi: 10.1128/EC.3.4.932-943.2004. PMID: 15302826; PMCID: PMC500880.
[2] Altman JK, Szilard A, Konicek BW, Iversen PW, Kroczynska B, Glaser H, Sassano A, Vakana E, Graff JR, Platanias LC. Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors. Blood. 2013 May 2;121(18):3675-81. doi: 10.1182/blood-2013-01-477216. Epub 2013 Mar 18. PMID: 23509154; PMCID: PMC3643766.
