CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+T cell and NK cell cytotoxicity.

推荐稀释比 WB:1/500-1/1000; IHC:1/100-1/200; IF:1/50-1/200; FC:1/50-1/100

Western blot analysis of LAMP1 in Hela (1), Ecv304 (2), A431 (3) and MCF-7 (4)cell lysate using LAMP1 antibody.

Immunohistochemistry analysis of paraffin-embedded human prostatic cancer tissues using LAMP1 antibody.

Immunocytochemistry analysis of LAMP1 in Hela cells using LAMP1 antibody (green),and DAPI(blue). Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Flow Cytometry analysis of Hek293 cells using LAMP1 antibody (green) and negative control (red).

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.