FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

推荐稀释比 WB:1/500-1/2000; IHC/-1/100-1/300; IF:1/50-1/200; ELISA:1/20000

Western blot analysis of FOXP3 in PC-12 lysates using FOXP3 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsilla using FOXP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human bladder cancer using FOXP3 antibody. High-pressure and temperature Tris-EDTA was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human colon using FOXP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human colon using FOXP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded Human colon using FOXP3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

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