SMAD4 family member 4, also known as SMAD4, is a protein that in human is encoded by the SMAD4 gene. It is often found mutated in many cancers. It acts as a tumor suppressor that functions in the regulation of the TGF-? signal transduction pathway, which negatively regulates growth of epithelial cells and the extracellular matrix (ECM). SMAD4 alterations have been found in multiple colorectal cancer and pancreatic carcinoma. It is found inactivated in at least 50% of pancreatic cancers. It is also found mutated in the autosomal dominant disease juvenile polyposis syndrome (JPS).

推荐稀释比 ELISA:1/1000-1/2000;WB:1/500-1/1000;IHC-P:1/50-1/100

Immunofluorescence of cells expressing SMAD4 proteins with Anti-SMAD4(R361H) antibody. HEK293T cells were transfected with pCDNA3-GFP-SMAD4(R361H) plasmid pCDNA3-GFP-SMAD4 (WT) plasmid, pCDNA3-GFP-SMAD4 (R361S) plasmid or pCDNA3-GFP-SMAD4 (R361C) plasmid, then fixed and stained with Anti-SMAD4(R361H) monoclonal antibody.

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