The A146T mutation of KRas results in an amino acid substitution at position 146, from an alanine to a threonine. KRAS encodes a protein that is a member of the small GTPase superfamily. Ras A146T mutation results in decreased GTPase activity and constitutive signaling. It can be found in many tumors, such as lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.

推荐稀释比 ELISA:1/1000-1/5000;WB:1/500-1/1000;IHC-P:1/50-1/100

Western blot analysis of recombinant HRAS(A146T) and wild type proteins. Purified His-tagged RAS(A146T) protein (lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-RAS(A146T) monoclonal antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。