MBNL2 mediates pre-mRNA alternative splicing regulation. It acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. It antagonizes the alternative splicing activity pattern of CELF proteins. It is an RNA-binding protein that binds to 5'ACACCC-3' core sequence within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs.

推荐稀释比 WB:1/500-1/1000;IHC-P:1/50-1/100

Western blot analysis of MBNL2 in lysates of HeLa,HepG2,Mouse brain and Rat liver using MBNL2 antibody.

Immunohistochemistry analysis of paraffin-embedded Human ovary using MBNL2 antibody.High pressure and temperature Tris/EDTA (PH 9.0) used for antigen retrieval.The brown color represents the positive signal observed with MBNL2 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。