Ataxia telangiectasia mutated (ATM) is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Activity of ATM protein is under tight control, and mutation of ATM can cause disease such as Ataxia telangiectasia (AT) and cancers.

推荐稀释比 ELISA:1/1000-1/5000;WB:1/100-1/1000;IHC-P:1/50-1/500

Western blot analysis of recombinant ATM(R2443Q) and wild type proteins.Purified His-tagged ATM(R2443Q) protein (amino acids 2400-3056, lane 2) and corresponding wild type protein (lane 1) were blotted with Anti-ATM(R2443Q) mouse monoclonal antibody.

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