mitogen-activated protein kinase kinase kinase 8(MAP3K8) Homo sapiens This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;IF:1/50-1/200;ELISA:1/10000

Western blot analysis of Phospho-COT (Thr290) in 293 lysates treated with UV using Phospho-COT (Thr290) antibody. The lane on the right is blocked with the Phospho- peptide.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。