MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation. Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

推荐稀释比 WB:1/500-1/1000

Western blot analysis of Phospho-MEK1 (Thr292) in (1) HeLa lysates; (2) HeLa cell treated with Nocodazole using Phospho-MEK1 (Thr292) antibody.

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