EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).

推荐稀释比 ELISA:1/1000-1/5000;WB:1/500-1/1000

Western blot analysis of recombinant EGFR(E746-A750) and wild type proteins.Purified His-tagged EGFR(E746-A750)del protein (aa 702-987) and wild type protein (aa 702-987) were blotted with anti- EGFR(E746-A750)del mouse antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。