The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease.

推荐稀释比 WB:1/500-1/1000;IF:1:50/1:200

Western blot analysis of Filamin A phosphorylation in WT-LRRK2 lysates treated LRRK2 using Phospho-LRRK2 (Ser935) antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。