EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLC gamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (NSCLC).

推荐稀释比 ELISA:1/1000-1/5000;WB:1/1000-1/5000;IHC-P:1/50-1/100

Western blot analysis of recombinant EGFR(vIII) and wild type proteins.Purified His-tagged EGFR(vIII) protein (partial, lane 2) and corresponding wild type protein (lane 1) were blotted with anti-EGFR(vIII) mouse monoclonal antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。