Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca2+ ions. Regulates the release of lumenal Ca2+ via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.

推荐稀释比 WB:1/500-1/1000;IHC-P:1/50-1/100

Western blot analysis of Calsequestrin 2 in lysates of Rat skeletal muscle,Rat heart,Mouse muscle and Mouse heart using Calsequestrin 2 antibody.

Immunohistochemistry analysis of paraffin-embedded Rat skeletal muscle using Calsequestrin 2 antibody.High pressure and temperature Tris/EDTA (PH 9.0) used for antigen retrieval.The brown color represents the positive signal observed with Calsequestrin 2 antibody.

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