Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.

推荐稀释比 WB:1/500-1/1000;IHC:1/50-1/100;ICC-1/100-1/200

Western blot analysis of Phospho-LIM Kinase 2 (Thr505) in Hela lysates using Phospho-LIM Kinase 2 (Thr505) antibody.

Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using LIMK2(Phospho-Thr505) antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Sample with blocking peptide on the right.

Immunofluorescence analysis of Phospho-LIM Kinase 2 (Thr505) in Hela cells using LIMK2(Phospho-Thr505) antibody(red).

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