Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

推荐稀释比 WB:1/500-1/1000;IHC:1/100-1/200;FC:1/50-1/100;ELISA:1/10000

Western blot analysis of APEX1 in Hela (1), Jurkat (2), SW480 (3), A431 (4), HepG2 (5), NIH/3T3 (6), and PC-12 (7) cell lysate using APEX1 antibody.

-25 ~ -15℃保存，收到货之后有效期1年，避免反复冻融。